Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in QatarArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] 95% confidence interval adjusted odds ratio Analysis BA.2 case-control study conducted Control control group controls COVID-19 COVID-19 severity Critical Disease progression drug Effectiveness eligible Epidemiology Evidence fatal COVID-19 food form high-risk patient higher risk incidence individual Mild-to-moderate neutralizing antibody occurred omicron Patient progression protective effect receive reducing SARS-CoV-2 Sotrovimab Sotrovimab. study period Subgroup analysis subgroup of patient Treatment treatment group United State [DOI] 10.1016/j.ijid.2022.09.023 PMC 바로가기
Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN studyArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] SARS, 진단, 치료기술, [키워드] age analysed anti-S anti-SARS-CoV-2 antibody association Case-control case-control study controls correlated fixed Gender identify Immunity Increasing infected individual Infection Linear regression Live virus logistic regression models Neutralising Antibodies no difference nucleocapsid occurred performed pre-vaccination protective effect pseudovirus reduced risk Reinfection required Result SARS-CoV-2 SARS-CoV-2 serology. serological serology serum sample significantly lower SIREN study tested titre titres vaccination Wuhan [DOI] 10.1016/j.jinf.2022.09.004 PMC 바로가기
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics proteomics. Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccineArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analyzed antibody Antibody titer B cell booster booster dose caused Cell Cluster Concentration conducted COVID-19 COVID-19 vaccine CyTOF Cytometry declined decrease distribution Efficacy ENhance healthy highlight humoral Immune cell immune response Immunity immunization immunoassay immunoassay. immunological profile inactivated individual injection Injections lack maintain marker multicenter neutralizing antibody not significantly different participant prevalence of COVID-19 proportion protective effect recall receiving recruited reduced SARS-CoV-2 second dose serum antibody shown significantly significantly increased Still subject surface marker sVNT the antibody response the vaccine vaccination Vaccine vaccine doses vaccine injection Viral variants virus neutralization test [DOI] 10.1002/jmv.27983 PMC 바로가기
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort studyArticle Published on 2022-10-052022-11-16 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] age analysed association clinical co-morbidity Cohort confounder Controlled trial Coronavirus disease 2019 COVID-19 defined Dexamethasone disease Effectiveness EPR Gender hazard hospital Hydrocortisone hypoxia in-hospital mortality individual Methylprednisolone Mortality multivariable multivariate model outcome Patient positive patient Prednisolone protective effect randomised clinical trial reduce replicate replicated reported retrospective cohort study Retrospective study risk SARS-CoV-2 RNA SARS-CoV-2 variant severe COVID-19 shown steroid steroid treatment steroids. treated Treatment viral genome was measured [DOI] 10.1186/s12879-022-07750-3 PMC 바로가기
Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreakArticle Published on 2022-10-012022-11-16 Journal: American journal of infection control [Category] COVID19(2023년), SARS, 변종, [키워드] affected attack Care Cluster complications COVID19 demonstrated diagnosed diagnostic dialysis disease incidence effective Effectiveness effort Epidemiology ESRD Genomics greater help Hemodialysis Infection infection control Infection prevention Intervention measure Measures mitigate morbidity Nosocomial transmission outbreak Patient patients positive protective effect provided receiving reducing risk robust RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 genome sequence SARS-COV-2 infection specimens Support Transmission vaccination Viral epidemiology. Viral genome sequencing while [DOI] 10.1016/j.ajic.2022.06.025 PMC 바로가기
Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in DenmarkArticle Published on 2022-09-302022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] Breakthrough infection Contact Denmark Follow-up household household contact Infection omicron protective effect Ratio reduce SAR SARS Coronavirus SARS-CoV-2 secondary attack rate Secondary infection susceptibility Transmission dynamics transmission of SARS-CoV-2 vaccinated individuals vaccination variant [DOI] 10.1038/s41467-022-33498-0 PMC 바로가기